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Cayman Chemical 3AmInopropylphosphonIc ACD
SDP

Supplier:  Cayman Chemical 23556100 MG

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A metabolite of all-trans retinoic acid formed through metabolism of all-trans retinoic acid by CYP26A1 B1 and C1 binds to RARs with a lower affinity than other all-trans retinoic acid metabolites (IC50s 606 298 and 892 nM for RARa RARB and RARY respectively in a radioligand binding assay) transactivates RARs with a lower efficacy than other metabolites (EC50s 791 64 and 94 nM for RARa RARB and RARY respectively) but induces transcription of a reporter plasmid equipotently inhibits cell growth halts the cell cycle in the G1 phase and induces differentiation of NB4 acute promyelocytic leukemia cells (EC50 79 8 nM)

Catalog No. 50-299-4673


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