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Apexbio Technology LLC 3CAI 28755-03-5 5mg
Supplier: Apexbio Technology LLC B46885
3CAI (CAS 28755-03-5) is a small molecule allosteric inhibitor selectively targeting AKT serine/threonine kinases Acting via an ATP-noncompetitive mechanism 3CAI binds directly to AKT1 and AKT2 exhibiting an IC50 of 1 M and suppressing 60% of AKT1 kinase activity at this concentration In vitro 3CAI reduces the expression of downstream AKT targets such as mTOR and GSK3 and at 4 M induces growth inhibition and apoptosis in HCT116 and HCT29 colon cancer cells Oral administration at 30 mg/kg significantly inhibits tumor growth and AKT substrate expression in mouse xenograft models 3CAI is valuable for studying AKT signaling and its implications in cancer research
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