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Medchemexpress LLC (3S,4S)-PF-06459988 | 1858291-14-1 | 99.0% | 431.88 | 100 MG
Supplier: Medchemexpress LLC HY19985A100MG
(3S, 4S)-PF-06459988 is the S enantiomer of PF-06459988 with less activity. PF-06459988 is a potent irreversible inhibitor of T790M mutant epidermal growth factor receptor (EGFR). It exhibits excellent selectivity against EGFR wild-type and has a minimally reactive electrophile to reduce off-target labeling. This compound is for research use only and not sold to patients.
- Inhibition of EGF-stimulated wild type EGFR autophosphorylation expressed in human A549 cells
- Inhibition of EGFR L858R/T790M double mutant autophosphorylation in human NCI-H1975 cells
- Excellent selectivity against EGFR wild-type
- Minimally reactive electrophile reduces off-target labeling
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