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Medchemexpress LLC 4-[[4-[4-[(E)-2-cyanoethenyl]-2,6-dimethylphenoxy]-7,8-dihydro-5H-thiopyrano[4,3-d]pyrimidin-2-yl... | 2826996-78-3 | 98.0% | C25H21N5OS | 10MG
SDP

Catalog No. 5000260968
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HIV-1 inhibitor-8 is an orally active small-molecule non-nucleoside reverse transcriptase inhibitor (NNRTI) used in research to probe HIV-1 replication and reverse transcriptase function. It shows potent antiviral activity in cellular assays, low cytotoxicity, and demonstrated favorable pharmacokinetic properties in rodent studies. The compound is supplied as a light yellow to light brown solid with high analytical purity suitable for biochemical and cellular experiments.

  • Potent antiviral activity (EC50 = 4.44-54.5 nM) against various HIV-1 strains.
  • Inhibits wild-type HIV-1 reverse transcriptase (IC50 = 0.081 μM).
  • Low cytotoxicity (CC50 = 284 μM) and high selectivity index.
  • High purity and stable solid form for reliable experimental use.
  • Good solubility in DMSO (50 mg/mL) for in vitro assays.
  • Low hERG inhibition and favorable in vivo pharmacokinetic profile in rodents.

Catalog No. 50-002-60968 Supplier Medchemexpress LLC Supplier No. HY13229110MG
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HIV-1 inhibitor-8 is an orally active small-molecule non-nucleoside reverse transcriptase inhibitor (NNRTI) used in research to probe HIV-1 replication and reverse transcriptase function. It shows potent antiviral activity in cellular assays, low cytotoxicity, and demonstrated favorable pharmacokinetic properties in rodent studies. The compound is supplied as a light yellow to light brown solid with high analytical purity suitable for biochemical and cellular experiments.

  • Potent antiviral activity (EC50 = 4.44-54.5 nM) against various HIV-1 strains.
  • Inhibits wild-type HIV-1 reverse transcriptase (IC50 = 0.081 μM).
  • Low cytotoxicity (CC50 = 284 μM) and high selectivity index.
  • High purity and stable solid form for reliable experimental use.
  • Good solubility in DMSO (50 mg/mL) for in vitro assays.
  • Low hERG inhibition and favorable in vivo pharmacokinetic profile in rodents.

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