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Medchemexpress LLC 4,4'-Sulfonyldiphenol | 80-09-1 | 99.4% | 250.28 | 50 G
SDP

Catalog No. 5000452853
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4,4'-Sulfonyldiphenol (Bisphenol S; Bis(4-hydroxyphenyl) sulfone) is a substitute for Bisphenol A, widely used in industrial and consumer products. It acts as an estrogen receptor (ER) agonist and binds to thyroid hormone receptors (TR). It promotes glioblastoma progression, causes lipid deposition in the liver, contributes to obesity at low doses, and induces intestinal inflammation. It also accelerates atherosclerosis progression in zebrafish embryo larvae.

  • Competitively binds to thyroid hormone receptors (TR) (IC50 for TRα: 2650 μM; TRβ: 2294 μM).
  • Affects breast development and reduces AR expression in fetal testes.
  • Promotes glioblastoma progression via EZH2-mediated PI3K/AKT/mTOR pathway upregulation.
  • Increases lipid deposition in AML12 and primary hepatocytes via the JunB/ATF3 axis in vitro.
  • Enhances foam cell formation with oxidized low-density lipoprotein (oxLDL) in macrophages in vitro.

Catalog No. 50-004-52853 Supplier Medchemexpress LLC Supplier No. HYW01192750G
May include imposed supplier surcharges.
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4,4'-Sulfonyldiphenol (Bisphenol S; Bis(4-hydroxyphenyl) sulfone) is a substitute for Bisphenol A, widely used in industrial and consumer products. It acts as an estrogen receptor (ER) agonist and binds to thyroid hormone receptors (TR). It promotes glioblastoma progression, causes lipid deposition in the liver, contributes to obesity at low doses, and induces intestinal inflammation. It also accelerates atherosclerosis progression in zebrafish embryo larvae.

  • Competitively binds to thyroid hormone receptors (TR) (IC50 for TRα: 2650 μM; TRβ: 2294 μM).
  • Affects breast development and reduces AR expression in fetal testes.
  • Promotes glioblastoma progression via EZH2-mediated PI3K/AKT/mTOR pathway upregulation.
  • Increases lipid deposition in AML12 and primary hepatocytes via the JunB/ATF3 axis in vitro.
  • Enhances foam cell formation with oxidized low-density lipoprotein (oxLDL) in macrophages in vitro.

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