4',5,7-Trihydroxyflavone, 97%

Description

CAS: 520-36-5 | C15H10O5 | 270.24 g/mol

4',5,7-Trihydroxyflavone is a nonmutagenic flavonoid shown to inhibit cell proliferation, angiogenesis and protein kinase. Also induces apoptosis in breast cancer cells. It inhibit topoisomerase I-catalyzed DNA re-ligation and enhance gap junctional intercellular communication.

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

Applications
4′,5,7-Trihydroxyflavone is a nonmutagenic flavonoid shown to inhibit cell proliferation, angiogenesis and protein kinase. Also induces apoptosis in breast cancer cells. It inhibit topoisomerase I-catalyzed DNA re-ligation and enhance gap junctional intercellular communication.

Solubility
Soluble in dimethyl sulfoxide (27 mg/ml) or 1M potassium hydroxide (50mg/ml).

Notes
Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Incompatible with and strong oxidizing agents.

Specifications

Chemical Identifiers

• CAS: 520-36-5
• Molecular Formula: C15H10O5
• Molecular Weight (g/mol): 270.24
• MDL Number: MFCD00006831
• InChI Key: KZNIFHPLKGYRTM-UHFFFAOYSA-N
• Synonym: apigenin, 5,7-dihydroxy-2-4-hydroxyphenyl-4h-chromen-4-one, chamomile, spigenin, versulin, apigenol, 4',5,7-trihydroxyflavone, apigenine, c.i. natural yellow 1, 5,7,4'-trihydroxyflavone
• PubChem CID: 5280443
• ChEBI: CHEBI:18388
• IUPAC Name: 5,7-dihydroxy-2-(4-hydroxyphenyl)chromen-4-one
• SMILES: OC1=CC=C(C=C1)C1=CC(=O)C2=C(O)C=C(O)C=C2O1

• Melting Point: ∽315°C (decomposition)
• Quantity: 25 mg
• Beilstein: 262620
• Merck Index: 14,730
• Solubility Information: Soluble in dimethyl sulfoxide (27mg/ml) or 1M potassium hydroxide (50mg/ml).
• Formula Weight: 270.24
• Percent Purity: 97%
• Chemical Name or Material: 4',5,7-Trihydroxyflavone

Safety and Handling

Hazard Category	H315-H319-H335
Hazard Statement	GHS H Statement H315-H319-H335 Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.
Precautionary Statement	P261-P264b-P271-P280-P302+P352-P304+P340-P305+P351+P338-P312-P332+P313-P362-P501c
EINECSNumber	208-292-3
RTECSNumber	LK9276000
TSCA	No
Recommended Storage	Keep cold

SDS

RUO – Research Use Only