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Medchemexpress LLC [4-[[5-chloro-4-(methylamino)-7H-pyrrolo[2,3-d]pyrimidin-2-yl]amino]-3-methoxyphenyl]-4-morpholinyl- | 1700693-08-8 | MFCD29472241 | 98.0% | 416.86 g/mol | C19H21ClN6O3 | 10 MG
SDP

Supplier:  Medchemexpress LLC HY1693610MG

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JH-II-127 is an orally active, highly potent, selective, and brain-permeable inhibitor of leucine-rich repeat kinase 2 (LRRK2) used in preclinical research to probe LRRK2 signaling and Parkinson's disease models. It shows low-nanomolar activity against wild-type and mutant LRRK2 and has characterized solubility and storage profiles for in vitro and in vivo studies.

  • Highly potent LRRK2 inhibition (low-nanomolar IC50 values).
  • Selective activity against wild-type and mutant LRRK2 variants.
  • Brain permeable, suitable for central nervous system studies.
  • High purity solid with defined storage conditions for stability.
  • Documented solubility protocols for in vitro and in vivo use.

Catalog No. 50-002-98359


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