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Medchemexpress LLC 4-[(5-methyl-1H-pyrazol-3-yl)amino]-2-phenyl-1(2H)-phthalazinone | 880487-62-7 | MFCD28399120 | 98.0% | 317.34 | C18H15N5O | 50MG
SDP

Supplier:  Medchemexpress LLC HY1256450MG

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Phthalazinone pyrazole is a potent, selective, orally active small-molecule inhibitor of Aurora-A kinase intended for laboratory research. It arrests mitosis and induces apoptosis in proliferating cells, and has been reported to modulate epithelial-mesenchymal transition during cellular differentiation. Supplied as a high-purity solid for biochemical and cellular studies.

  • Potent Aurora-A kinase inhibitor (IC50 = 0.031 μM).
  • Demonstrated cellular activity in multiple cancer cell lines (MCF7 IC50 1.6 μM; COLO 205 IC50 2.9 μM; HCT-116 IC50 7.8 μM).
  • High purity (98.0%).
  • Molecular weight 317.34; formula C18H15N5O.
  • Supplied as a brown to gray solid; recommended solvent DMSO (≥ 11.11 mg/mL).
  • Store solid at 4°C protected from light; in solution store at -80°C for long-term stability.

Catalog No. 50-002-36420


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