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Medchemexpress LLC 4-[(5-methyl-1H-pyrazol-3-yl)amino]-2H-phenyl-1-phthalazinone | 880487-62-7 | MFCD28399120 | 98.0% | 317.34 g/mol | C18H15N5O | 100MG
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Supplier:  Medchemexpress LLC HY12564100MG

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Phthalazinone pyrazole is a small-molecule research compound and a potent, selective, orally active inhibitor of Aurora-A kinase (IC50 = 0.031 μM). It arrests mitosis and induces apoptosis in proliferating cells, and has been reported to suppress epithelial-mesenchymal transition in certain differentiation studies. The compound has molecular formula C18H15N5O, molecular weight 317.34 g·mol⁻¹, CAS 880487-62-7, and is supplied at high purity for research use.

  • Potent Aurora-A kinase inhibition (IC50 = 0.031 μM).
  • Selective activity with limited Aurora-B inhibition at tested concentrations.
  • Induces mitotic arrest and subsequent apoptosis in proliferating cells.
  • Reported to suppress epithelial-mesenchymal transition in differentiation models.
  • Molecular formula C18H15N5O; molecular weight 317.34 g·mol⁻¹; CAS 880487-62-7.
  • Supplied at high purity (≥98%) for research use.
  • Available in multiple pack sizes including 100 mg.

Catalog No. 50-002-37945


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