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Bachem 4-ALKOXYBENZYL ALCOHOL R/ 25G
Supplier: Bachem 4003214.0025
Wang resin#4-Benzyloxybenzyl alcohol resin#4-HOCH₂-Ph-O-CH₂-Ph-polymer. 25g. MFCD00131778. The Wang support, p-benzyloxybenzyl alcohol resin, is the most widely used resin for attaching carboxylic acids for further functionalization. Cleavage conditions for the ester anchor involve concentrated TFA or TFA/CH₂Cl₂ to provide carboxylic acids or cyclization-cleavage under acidic or basic conditions. Release of an amide function by treatment with an amine in the presence of a Lewis acid was also reported. Wang resin was used to add vinyl and iodobenzoic acids via carbodiimide coupling and the products subjected to Heck conditions with alkenes or with alkynes or to Suzuki coupling with boron reagents. The Ugi multicomponent condensation reaction was conducted on Wang resin with the carboxylic acid, amine or isonitrile as the anchored functional group.
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