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Cayman Chemical 4-AmInosalIcylIc AcId 250g
Supplier: Cayman Chemical 33449250 G
A PABA antimetabolite with antibacterial activity; active against streptomycin-sensitive and -resistant strains of M. tuberculosis (MICs = 0.78 and 0.39 UG/ml, respectively); an alternative substrate for FolP1 and misincorporation into the folate pathway leads to accumulation of several folate-dependent metabolites including serine, homocysteine, dUMP, and AICAR, markers of folate pathway inhibition, in a concentration-dependent manner; reverses manganese-induced increases in rat hippocampal levels of NLRP3, cleaved caspase-1, and phosphorylated p65 at 300 mg/kg; a synthetic building block
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