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Cayman Chemical 4-deoxy PyrIdoxInhydrochlo 1g

Supplier: Cayman Chemical 218631 G

A potent inhibitor of HDAC6 (IC50 0 40 nM) selective for HDAC6 over HDAC3 (IC50 51 61 nM) induces a-tubulin acetylation an HDAC6-dependent process with minimal effect on global lysine acetylation inhibits growth of patient-derived multiple myeloma cell lines (IC50s 1 5-4 7 M) enhances cytotoxicity of bortezomib and carfilzomib against patient-derived multiple myeloma cells decreases tumor size in a human MM 1S multiple myeloma mouse xenograft model when administered in combination with bortezomib at doses of 50 and 0 5 mg/kg respectively
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