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Medchemexpress LLC (4-methyl-6-phenylpyridazin-3-yl)-(4-pyrimidin-2-ylpiperazin-1-yl)methanone | 1252608-59-5 | MFCD31544336 | 99.9% | 360.41 g/mol | C20H20N6O | 25 MG
SDP

Supplier:  Medchemexpress LLC HY10186025MG

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GIBH-130 is a small-molecule research compound that inhibits neuroinflammation by suppressing IL-1β secretion from activated microglia (IL-1β IC50 = 3.4 nM). It is orally bioavailable in rodents, shows blood-brain barrier penetration, and has demonstrated in vivo activity in models of cognitive impairment. Supplied as an off-white to pink solid for laboratory research use.

  • Potent IL-1β inhibition (IC50 3.4 nM).
  • Orally bioavailable with measurable brain penetration in rats.
  • Demonstrated efficacy in rodent cognitive-impairment models.
  • Also inhibits NO and TNF-α at micromolar concentrations.
  • High purity solid, suitable for research applications and formulation studies.

Catalog No. 50-002-46589


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