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Cayman Chemical 4-MethylumbelIferylD-Gluc 1g

Supplier: Cayman Chemical 209481 G

An inhibitor of type I PRMTs (IC50s 30 119 83 4 and 5 nM for PRMT1 -3 -4 -6 and -8 respectively) selective for these type I PRMTs over PRMT5 -7 and -9 as well as a panel of 25 PKMTs and DNMTs at 10 UM inhibits methylation of H4R3 in MCF-7 cells and H3R2 in HEK293 cells (IC50s 9 and 56 nM respectively) inhibits methylation of the SARS-CoV-2 nucleocapsid protein and the replication of SARS-CoV-2 in Vero E6 cells at 20 UM reduces tumor growth in a Huh7 mouse xenograft model at 160 mg/kg
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