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Cayman Chemical 4-octyl Itaconate, 3133-16-2, 100 mg

Supplier: Cayman Chemical 25374100

Molecular Formula C13H22O4, Purity ≥98% (mixture of tautomers), Formula Weight 242.3, Synonyms: 2-methylene-butanedioic acid, 4-octyl ester; A prodrug form of itaconate; hydrolyzed to itaconate by esterases in C2C12 cells and LPS-activated mouse macrophages; increases Nrf2 protein levels and expression of Nrf2 target genes and enhances LPS-induced Nrf2 stabilization in mouse macrophages; decreases serum levels of IL-1 and TNF-, increases Nrf2 protein expression, and protects against LPS-induced lethality in wild-type, but not Nrf2 knockout, mice at 50 mg/kg.
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