Medchemexpress LLC 4-Oxazolecarboxamide, N-[6-[(2-methoxyethyl)methylamino]-3-pyridinyl]-2-phenyl-5-(trifluoromethyl)- | 939375-07-2 | 99.9% | 420.39 | 5 MG

Supplier:  Medchemexpress LLC HY164345MG

DGAT1-IN-3 is a potent, selective, and orally bioavailable inhibitor of DGAT-1, with IC50s of 38 nM for human DGAT-1 and 120 nM for rat DGAT-1. It can be used for research on obesity, dyslipidemia, and metabolic syndrome.

• Potent, selective, and orally bioavailable inhibitor of DGAT-1.
• IC50s: 38 nM (human DGAT-1); 120 nM (rat DGAT-1).
• Reduces weight gain and plasma triglycerides, and improves lipid profile in animal models.
• Exhibits good oral bioavailability (77%) and a maximum exposure level in plasma (Cmax) of 24 μM (50 mg/kg; p.o).
• Exhibits terminal elimination half-lives (1.95 h) and low clearance (13.5 mL/min/kg) (5 mg/kg; i.v).
• Appearance: solid, light yellow to yellow color.

Catalog No. 50-003-94191