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Medchemexpress LLC 4-Piperidinamine, 1-[3-(2,3-dichlorophenyl)-1H-pyrazolo[3,4-b]pyrazin-6-yl]-4-methyl- | 2160546-07-4 | 100.0% | 377.27 | 5 MG
SDP

Supplier:  Medchemexpress LLC 5MGHY137092

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IACS-13909 is a selective, potent, and orally active SHP2 allosteric inhibitor. It exhibits greater selectivity for SHP2 over other phosphatases, including SHP1. This compound demonstrates antitumor activities and suppresses MAPK pathway signaling in receptor tyrosine kinase (RTK)-dependent cancers.

  • Potently suppresses the proliferation of wild-type SHP2 and KYSE-520 cells.
  • Suppresses pERK and pMEK levels in wild-type SHP2 and KYSE-520 cells.
  • Inhibits the proliferation of parental cells and NCI-H1975 CS cells in a dose-dependent manner.
  • Achieved 100% tumor growth inhibition (TGI) in mice studies.
  • Functions as a selective SHP2 allosteric inhibitor with an IC50 of 15.7 nM and a Kd of 32 nM.

Catalog No. 50-003-64203


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