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Medchemexpress LLC 4-Quinolinamine, N-5-benzothiazolyl-6-[(1-methylethyl)sulfonyl]- | 1346546-69-7 | 99.9% | 383.49 | 50 MG
SDP

Supplier:  Medchemexpress LLC 50MGHY101872

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GSK-872 is a potent RIPK3 inhibitor that binds to the RIP3 kinase domain with an IC50 of 1.8 nM and inhibits kinase activity with an IC50 of 1.3 nM. It effectively decreases RIPK3-mediated necroptosis, subsequent cytoplasmic translocation, and expression of HMGB1. This compound also demonstrates the ability to ameliorate brain edema and neurological deficits in early brain injury models.

  • Targets RIPK3.
  • Binds RIP3 kinase domain with an IC50 of 1.8 nM.
  • Inhibits kinase activity with an IC50 of 1.3 nM.
  • Decreases RIPK3-mediated necroptosis.
  • Reduces cytoplasmic translocation and expression of HMGB1.
  • Ameliorates brain edema and neurological deficits in early brain injury.
  • For research use only.

Catalog No. 50-003-65942


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