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Medchemexpress LLC 4-Quinolinemethanol, 6,8-dichloro-α-2-piperidinyl-2-tricyclo[3.3.1.13,7]dec-1-yl- | 785718-37-8 | 98.6% | 445.42 | 50 MG
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Catalog No. 5000385141
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NSC305787 is an inhibitor of ezrin with a Kd of 5.85 μM. It inhibits the phosphorylation of ezrin caused by PKCΙ with an IC50 of 8.3 μM, and exhibits antitumor activity. NSC305787 also inhibits PKCΙ phosphorylation of Moesin, Radixin, and MBP. It primarily inhibits ezrin T567 phosphorylation through binding to ezrin rather than by inhibiting PKCΙ kinase activity.

  • Inhibitor of ezrin with a Kd of 5.85 μM
  • Inhibits phosphorylation of ezrin caused by PKCΙ with an IC50 of 8.3 μM
  • Exhibits antitumor activity
  • Inhibits PKCΙ phosphorylation of Moesin, Radixin, and MBP
  • Primarily inhibits ezrin T567 phosphorylation by binding to ezrin
  • Shows inhibitory activity against ezrin-mediated invasion of K7M2 osteosarcoma (OS) cells
  • Reduces cell motility phenotypes in zebrafish
  • Blocks OS metastatic growth in lung organ culture

Catalog No. 50-003-85141 Supplier Medchemexpress LLC Supplier No. HY1893150MG
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NSC305787 is an inhibitor of ezrin with a Kd of 5.85 μM. It inhibits the phosphorylation of ezrin caused by PKCΙ with an IC50 of 8.3 μM, and exhibits antitumor activity. NSC305787 also inhibits PKCΙ phosphorylation of Moesin, Radixin, and MBP. It primarily inhibits ezrin T567 phosphorylation through binding to ezrin rather than by inhibiting PKCΙ kinase activity.

  • Inhibitor of ezrin with a Kd of 5.85 μM
  • Inhibits phosphorylation of ezrin caused by PKCΙ with an IC50 of 8.3 μM
  • Exhibits antitumor activity
  • Inhibits PKCΙ phosphorylation of Moesin, Radixin, and MBP
  • Primarily inhibits ezrin T567 phosphorylation by binding to ezrin
  • Shows inhibitory activity against ezrin-mediated invasion of K7M2 osteosarcoma (OS) cells
  • Reduces cell motility phenotypes in zebrafish
  • Blocks OS metastatic growth in lung organ culture

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