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ABclonal Technology 450 Rabbit anti-Human CD142
Supplier: ABclonal Technology A26456100T
This gene encodes coagulation factor III a cell surface glycoprotein that initiates blood coagulation by acting as a high-affinity receptor for factor VII The resulting complex triggers protease cascades via limited proteolysis Unlike other circulating cofactors factor III is fully active when expressed on cell surfaces such as monocytes It has three domains extracellular transmembrane and cytoplasmic Its expression is induced by procoagulatory and proinflammatory stimuli and is implicated in HIV-associated coagulopathy and COVID-19 severity Notably no congenital deficiency has been identified Multiple transcript variants arise from alternative splicing
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