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ABclonal Technology 488 anti-Human Megalin/LRP2
SDP

Catalog No. 5000009907
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The gene encodes low-density lipoprotein-related protein 2 (LRP2) or megalin a multi-ligand endocytic receptor primarily expressed in absorptive epithelial tissues like the kidney This glycoprotein has a large extracellular domain a transmembrane domain and a short cytoplasmic tail It binds various macromolecules such as albumin apolipoproteins B and E and lipoprotein lipase LRP2 is essential for the reuptake of lipoproteins sterols vitamin-binding proteins and hormones It also plays a role in cell signaling interacting with extracellular ligands like parathyroid hormone and sonic hedgehog and cytosolic ligands such as MAP kinase scaffold proteins Phosphorylation of its cytoplasmic domain regulates receptor recycling Mutations in this gene cause Donnai-Barrow syndrome (DBS) and facio-oculoacoustico-renal syndrome (FOAR)

Catalog No. 50-000-09907 Supplier ABclonal Technology Supplier No. A24715100T
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The gene encodes low-density lipoprotein-related protein 2 (LRP2) or megalin a multi-ligand endocytic receptor primarily expressed in absorptive epithelial tissues like the kidney This glycoprotein has a large extracellular domain a transmembrane domain and a short cytoplasmic tail It binds various macromolecules such as albumin apolipoproteins B and E and lipoprotein lipase LRP2 is essential for the reuptake of lipoproteins sterols vitamin-binding proteins and hormones It also plays a role in cell signaling interacting with extracellular ligands like parathyroid hormone and sonic hedgehog and cytosolic ligands such as MAP kinase scaffold proteins Phosphorylation of its cytoplasmic domain regulates receptor recycling Mutations in this gene cause Donnai-Barrow syndrome (DBS) and facio-oculoacoustico-renal syndrome (FOAR)

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