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ABclonal Technology 488 Rabbit anti-Human CD40
Supplier: ABclonal Technology A21938200T
This gene is a member of the TNF-receptor superfamily and encodes a receptor on antigen-presenting cells essential for immune and inflammatory responses including T cell-dependent immunoglobulin class switching memory B cell development and germinal center formation The AT-hook transcription factor AKNA regulates this receptor and its ligand playing a role in homotypic cell interactions The receptor s interaction with its ligand is vital for amyloid-beta-induced microglial activation an early event in Alzheimer s disease Mutations in this gene cause autosomal recessive hyper-IgM immunodeficiency type 3 (HIGM3) Multiple alternatively spliced variants encoding distinct isoforms have been reported
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