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ABclonal Technology 488 Rabbit anti-Human ERG
Supplier: ABclonal Technology A22496200T
This gene encodes a member of the ETS family of transcription factors which regulate embryonic development cell proliferation differentiation angiogenesis inflammation and apoptosis The protein contains an ETS DNA-binding domain and a PNT domain involved in self-association of oncoproteins It is primarily expressed in the nucleus and plays a role in platelet adhesion to the subendothelium vascular remodeling hematopoiesis and megakaryocyte differentiation This gene is involved in chromosomal translocations leading to fusion proteins like TMPSSR2-ERG in prostate cancer EWS-ERG in Ewing s sarcoma and FUS-ERG in acute myeloid leukemia Over two dozen transcript variants have been reported though the full-length forms of many are undetermined
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