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Cayman Chemical 4A7C-301-Nurr1 Agonist, Purity: ≥98%, 1 mg
SDP

Catalog No. 502917265
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A Nurr1 receptor agonist; binds to Nurr1-LBD (IC50 = 48.22 nM) and increases transcriptional activity of Nurr1-LBD and full-length Nurr1 in reporter assays using SK-N-BE(2)C human neuroblastoma cells (EC50s = 6.53 and 50-70 µM, respectively); decreases dopaminergic cell death in the striatum and substantia nigra pars compacta, as well as reduces motor and olfactory deficits, without inducing dyskinesia-like behaviors in MPTP- or α-synuclein-overexpression mouse models of Parkinson’s disease

Catalog No. 50-291-7265 Supplier Cayman Chemical Supplier No. 394531 MG
May include imposed supplier surcharges.
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A Nurr1 receptor agonist; binds to Nurr1-LBD (IC50 = 48.22 nM) and increases transcriptional activity of Nurr1-LBD and full-length Nurr1 in reporter assays using SK-N-BE(2)C human neuroblastoma cells (EC50s = 6.53 and 50-70 µM, respectively); decreases dopaminergic cell death in the striatum and substantia nigra pars compacta, as well as reduces motor and olfactory deficits, without inducing dyskinesia-like behaviors in MPTP- or α-synuclein-overexpression mouse models of Parkinson’s disease

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