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Medchemexpress LLC (4S)-PROTAC SOS1 degrader-1 | 2913176-81-3 | C57H76ClFN10O4S | 50 MG
SDP

Supplier:  Medchemexpress LLC HY144657A50MG

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(4S)-PROTAC SOS1 degrader-1 is a potent PROTAC SOS1 degrader. It decreases the expression of pERK and RAS-GTP levels in a dose-dependent manner. It also significantly inhibits tumor growth in vivo.

  • Shows potent SOS1 degradation activity with 56.2% and 92.5% SOS1 protein degradation at 0.1 and 1 μM, respectively, in NCI-H358 cells.
  • Degrades SOS1 in a dose- and time-dependent manner in NCI-H358 cells (24 h incubation).
  • Does not induce SOS2 and KRAS degradation in NCI-H358 cells (9.8-2500 nM; 24 h).
  • Decreases the expression of pERK and RAS-GTP levels in NCI-H358 cells in a dose-dependent manner (7.8-2000 nM; 24 h).
  • Significantly inhibits tumor growth in vivo.

Catalog No. 50-003-54818


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