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Medchemexpress LLC 5-(4-butoxy-3-chlorophenyl)-N-((2-morpholinopyridin-3-yl)methyl)nicotinamide | 1266212-81-0 | 99.1% | 480.99 | C26H29ClN4O3 | 25 MG
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Supplier:  Medchemexpress LLC HY10008025MG

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A-887826 is a potent, selective, voltage-dependent small-molecule blocker of the NaV1.8 (hNav1.8) sodium channel. Reported in peer-reviewed studies to block recombinant human NaV1.8 with an IC50 of ~11 nM, it is described as orally bioavailable and reduces neuropathic tactile allodynia in animal models. The compound is a nicotinamide/pyridine derivative (CAS 1266212-81-0).

  • Potent NaV1.8 inhibition (IC50 ≈ 11 nM).
  • Selective, voltage-dependent channel block.
  • Orally bioavailable in reported studies.
  • Demonstrated efficacy in neuropathic pain models.
  • Well-characterized chemical identity and CAS registration.
  • High reported purity (≈99.1%).
  • Molecular weight 480.99 and formula C26H29ClN4O3.

Catalog No. 50-002-15515


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