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Medchemexpress LLC 5-[6-[4-(1-piperazinyl)phenyl]pyrazolo[1,5-a]pyrimidin-3-yl]-quinoline | 1432597-26-6 | MFCD28099808 | >98.0% | 406.48 g·mol⁻1 | C25H22N6 | 10 MG
SDP

Supplier:  Medchemexpress LLC HY1589710MG

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LDN-212854 is a potent small-molecule inhibitor of bone morphogenetic protein (BMP) signaling with strong activity against activin receptor-like kinase 2 (ALK2). It is used as a research tool to study BMP signaling pathways, fibrodysplasia ossificans progressiva, and certain cancers such as hepatocellular carcinoma.

  • Potent ALK2 inhibition (IC50 ≈ 1.3 nM).
  • Also inhibits ALK1 with nanomolar potency.
  • Selectivity bias toward BMP versus TGF-β type I receptors.
  • Suitable for biochemical and cellular research applications.
  • Available in small milligram packs for assay screening.
  • Storage stability provided for powder and solution formats.

Catalog No. 50-002-88681


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