5-Aminoimidazole-4-carboxamide 1-beta-D-ribofuranoside, 98%, Thermo Scientific Chemicals

Description

Activator of AMP-activated protein kinase (AMPK)

5-Aminoimidazole-4-carboxamide 1-beta-D-ribofuranoside is used as a cell permeable activator of AMP-activated protein kinase (AMPK), a metabolic master regulator that is activated in times of reduced energy availability (high cellular AMP:ATP ratios) and serves to inhibit anabolic processes.

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

Applications
5-Aminoimidazole-4-carboxamide 1-beta-D-ribofuranoside is used as a cell permeable activator of AMP-activated protein kinase (AMPK), a metabolic master regulator that is activated in times of reduced energy availability (high cellular AMP:ATP ratios) and serves to inhibit anabolic processes.

Solubility
Soluble in DMSO at 2mg/ml. Soluble in water or ethanol at less than 1mg/ml

Notes
Store in cool, dry conditions in well sealed containers. Keep container tightly closed.

Specifications

Chemical Identifiers

• CAS: 2627-69-2
• Molecular Formula: C9H14N4O5
• Molecular Weight (g/mol): 258.23
• MDL Number: MFCD00869751
• InChI Key: RTRQQBHATOEIAF-UUOKFMHZSA-N
• Synonym: acadesine, aica-riboside, aicar, arasine, aica riboside, aic-riboside, acadesina, acadesinum, 5-amino-1-beta-d-ribofuranosyl-1h-imidazole-4-carboxamide, protara
• PubChem CID: 17513
• ChEBI: CHEBI:28498
• IUPAC Name: 5-amino-1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]imidazole-4-carboxamide
• SMILES: NC(=O)C1=C(N)N(C=N1)[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1O

• Melting Point: 214°C to 215°C
• Color: Brown
• Quantity: 50 mg
• Merck Index: 14,16
• Solubility Information: Soluble in DMSO at 2mg/ml; Soluble in water or ethanol at less than 1mg/ml
• Formula Weight: 258.23
• Percent Purity: 98%
• Physical Form: Powder
• Chemical Name or Material: 5-Aminoimidazole-4-carboxamide 1-beta-D-ribofuranoside

Safety and Handling

Hazard Category	H315-H319-H335
Hazard Statement	GHS H Statement H315-H319-H335 Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.
Precautionary Statement	P261-P264b-P271-P280-P302+P352-P304+P340-P305+P351+P338-P312-P332+P313-P362-P501c
EINECSNumber	220-097-5
TSCA	Yes
Recommended Storage	Store at -20°C

SDS

RUO – Research Use Only