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Medchemexpress LLC 5-Aminosalicylic acid | 89-57-6 | C7H7NO3 | 1 G

Supplier: Medchemexpress LLC HY150271G
5-Aminosalicylic acid (Mesalamine) is a specific PPARγ agonist that also inhibits p21-activated kinase 1 (PAK1) and NF-κB. It can also inhibit osteopontin (OPN) activity. This chemical demonstrates antineoplastic effects in xenograft tumor models and is used for research purposes.
- Specific PPARγ agonist.
- Inhibits p21-activated kinase 1 (PAK1) and NF-κB.
- Inhibits osteopontin (OPN) activity.
- Demonstrates antineoplastic effects in xenograft tumor models.
- Induces p65 degradation.
- Blocks NF-κB in intestinal epithelial cells (IECs) by inhibiting PAK1.
- Inhibits growth of HT-29 colon carcinoma cells in a dose and time-dependent manner.
- Potent inhibition of HT-29 colon carcinoma cell proliferation when combined with Nimesulide.
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