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Medchemexpress LLC 5-Aminosalicylic acid | 89-57-6 | C7H7NO3 | 1 G
SDP

Supplier:  Medchemexpress LLC HY150271G

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5-Aminosalicylic acid (Mesalamine) is a specific PPARγ agonist that also inhibits p21-activated kinase 1 (PAK1) and NF-κB. It can also inhibit osteopontin (OPN) activity. This chemical demonstrates antineoplastic effects in xenograft tumor models and is used for research purposes.

  • Specific PPARγ agonist.
  • Inhibits p21-activated kinase 1 (PAK1) and NF-κB.
  • Inhibits osteopontin (OPN) activity.
  • Demonstrates antineoplastic effects in xenograft tumor models.
  • Induces p65 degradation.
  • Blocks NF-κB in intestinal epithelial cells (IECs) by inhibiting PAK1.
  • Inhibits growth of HT-29 colon carcinoma cells in a dose and time-dependent manner.
  • Potent inhibition of HT-29 colon carcinoma cell proliferation when combined with Nimesulide.

Catalog No. 50-003-75582


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