5-Azacytidine, 98%

Description

Causes DNA demethylation or hemi-demethylation; a powerful mutagen | CAS: 320-67-2 | C8H12N4O5 | 244.21 g/mol

5-Azacytidine, its incorporation into RNA alters RNA synthesis and processing, and results in inhibition of protein synthesis. It has been used as a cancer chemotherapeutic agent. It is a powerful bacteriostatic, antitumor, and mutagenic agent; it also exhibits immunosuppressive, antimitotic, radioprotective, and virostatic effects.

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

Applications
5-Azacytidine, its incorporation into RNA alters RNA synthesis and processing, and results in inhibition of protein synthesis. It has been used as a cancer chemotherapeutic agent. It is a powerful bacteriostatic, antitumor, and mutagenic agent; it also exhibits immunosuppressive, antimitotic, radioprotective, and virostatic effects.

Solubility
Soluble in water.

Notes
Store in cool, dry conditions in well sealed containers. Keep container tightly closed.

Specifications

Chemical Identifiers

• CAS: 320-67-2
• Molecular Formula: C8H12N4O5
• Molecular Weight (g/mol): 244.21
• MDL Number: MFCD00006539
• InChI Key: NMUSYJAQQFHJEW-KVTDHHQDSA-N
• Synonym: 5-azacytidine, azacitidine, ladakamycin, azacytidine, vidaza, mylosar, azacitidina, azacitidinum, 5-azacitidine, azacitidinum inn-latin
• PubChem CID: 9444
• ChEBI: CHEBI:2038
• IUPAC Name: 4-amino-1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-1,2-dihydro-1,3,5-triazin-2-one
• SMILES: NC1=NC(=O)N(C=N1)[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1O

• Melting Point: 226°C to 232°C (decomposition)
• Color: White
• Quantity: 1 g
• Beilstein: 620461
• Merck Index: 14,890
• Solubility Information: Soluble in water.
• Formula Weight: 244.2
• Percent Purity: 98%
• Physical Form: Powder
• Chemical Name or Material: 5-Azacytidine

Safety and Handling

Hazard Category	H302-H340-H350
Hazard Statement	GHS H Statement H340-H350-H302 May cause genetic defects. May cause cancer. Harmful if swallowed.
Precautionary Statement	P201-P202-P264b-P270-P281-P301+P312-P308+P313-P330-P501c
EINECSNumber	206-280-2
RTECSNumber	XZ3017500
TSCA	No
Recommended Storage	Store at -20°C

SDS

RUO – Research Use Only