Thermo Scientific Chemicals 5-Azacytidine, 99%

Catalog No.	Quantity
AC226620500	50 mg
AC226620010	1 g

Catalog No. AC226620500 Supplier Thermo Scientific Chemicals Supplier No. 226620500

Description

5-Azacytidine, CAS # 320-67-2, is an chemical analog of cytidine that acts as an inhibitor of DNA methyltransferase activity. | CAS: 320-67-2 | C8H12N4O5 | 244.21 g/mol

This Thermo Scientific Chemicals brand product was originally part of the Acros Organics product portfolio. Some documentation and label information may refer to the legacy brand. The original Acros Organics product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

General Description

• 5-Azacytidine is a chemical analog of the nucleoside cytidine that incorporates into DNA and inhibits DNA methylation
• At low doses, 5-azacytidine irreversibly binds the enzyme DNA methyltransferase (DNMT)

Applications

• 5-Azacytidine has been used for cardiomyocyte differentiation from mesenchymal stem cells
• It has been used as a potent DNMT inhibitor in the study of tumor cell proliferation and induction of gene expression following demethylation
• 5-Azacytidine can globally change histone modification patterns

Specifications

Chemical Identifiers

• CAS: 320-67-2
• Molecular Formula: C8H12N4O5
• Molecular Weight (g/mol): 244.21
• MDL Number: MFCD00006539
• InChI Key: NMUSYJAQQFHJEW-KVTDHHQDSA-N
• Synonym: 5-azacytidine, azacitidine, ladakamycin, azacytidine, vidaza, mylosar, azacitidina, azacitidinum, 5-azacitidine, azacitidinum inn-latin
• PubChem CID: 9444
• ChEBI: CHEBI:2038
• IUPAC Name: 4-amino-1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-1,3,5-triazin-2-one
• SMILES: NC1=NC(=O)N(C=N1)[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1O

• CAS Min %: 98.5
• CAS Max %: 100.0
• Melting Point: 228.0°C to 230.0°C
• Color: White
• Infrared Spectrum: Authentic
• Assay Percent Range: 98.5% min. (HPLC)
• Packaging: Glass bottle
• Quantity: 50 mg
• Merck Index: 15, 884
• Specific Rotation: + 40.00
• Solubility Information: Solubility in water: .. Other solubilities: soluble in methanol
• Formula Weight: 244.21
• Percent Purity: 99%
• Physical Form: Crystalline Powder
• Chemical Name or Material: 5-Azacytidine, 99%

Safety and Handling

Hazard Category	GHS Signal Word: Danger
Hazard Statement	GHS H Statement Harmful if swallowed. May cause genetic defects. May cause cancer.
Precautionary Statement	GHS P Statement IF SWALLOWED: rinse mouth. Do NOT induce vomiting. Call a POISON CENTER or doctor/physician if you feel unwell. Wash face,hands and any exposed skin thoroughly after handling. Obtain special instructions before us
EINECSNumber	206-280-2
RTECSNumber	XZ3017500

SDS

RUO – Research Use Only