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Medchemexpress LLC 5-chloro-N-[2-(4-hydroxysulfamoyl-phenyl)-ethyl]-2-methoxybenzamide | 2112809-98-8 | 98.4% | 384.83 | C16H17ClN2O5S | 10 MG
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Supplier:  Medchemexpress LLC HY11743210MG

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JC-171 is a selective NLRP3 inflammasome inhibitor that blocks LPS/ATP-induced interleukin-1β (IL-1β) release from macrophages (IC50 = 8.45 μM). It has demonstrated activity in vitro and in vivo, including reduction of disease severity in mouse EAE models, and is supplied as a high-purity research chemical.

  • Selective NLRP3 inflammasome inhibitor; IC50 = 8.45 μM for LPS/ATP-induced IL-1β release in J774A.1 macrophages.
  • Shown to reduce disease severity in mouse EAE models and lower Th17 cell frequency.
  • High purity (98.4%); molecular weight 384.83 g·mol⁻¹; formula C16H17ClN2O5S.
  • Soluble ≥ 2.08 mg/mL in recommended vehicles for in vivo dosing.
  • Available in small research pack sizes, including 10 mg.
  • Recommended storage: powder at -20°C; prepared solutions at -80°C to limit freeze-thaw.

Catalog No. 50-002-26332


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