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AdipoGen 5-Hydroxyindole-3-acetic acid
Supplier: AdipoGen AGCR13544M100
Chemical. CAS 54-16-0. Formula C10H9NO3. Molecular Weight 191.2. 5-hydroxy Indole-3-acetic acid 5-HIAA is the primary metabolite of serotonin, metabolized by monoamine oxidase and aldehyde dehydrogenase in the liver. As the catabolic end product of the serotonin pathway, 5-HIAA is present in body fluids like cerebrospinal fluid CSF, blood and urine. It can be used as an internal standard for the quantification of serotonin metabolism. 5-HIAA is a potent GPR35 receptor ligand, an inflammatory mediator for immune and non-immune cell populations. 5-HIAA is secreted by platelets and mast cells during inflammation and by binding to neutrophils has a chemoattractant role. 5-HIAA deficient mice show a loss of GPR35-mediated neutrophil recruitment to inflamed tissue. The chemoattractant GPR35-5-HIAA receptor-ligand system cooperates with other inflammation-induced factors in mediating neutrophil recruitment to sites of inflammation.
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