Promotional price valid on web orders only. Your contract pricing may differ. Interested in signing up for a dedicated account number?
Learn More
Learn More
Medchemexpress LLC 5-(N,N-Hexamethylene)-amiloride | 1428-95-1 | 99.1% | 1 ML
Supplier: Medchemexpress LLC HY12806710MM/1ML
5-(N,N-Hexamethylene)-amiloride, also known as Hexamethylene amiloride (HMA), is a potent Na+/H+ exchanger inhibitor derived from amiloride. It effectively decreases intracellular pH (pHi) and has been shown to induce apoptosis in leukemic cells. This compound also acts as an inhibitor of the HIV-1 Vpu virus ion channel and inhibits the replication of mouse hepatitis virus (MHV) and human coronavirus 229E (HCoV229E) in cultured L929 cells.
- Potent Na+/H+ exchanger inhibitor
- Decreases intracellular pH (pHi)
- Induces apoptosis in leukemic cells
- Inhibits HIV-1 Vpu virus ion channel
- Inhibits replication of mouse hepatitis virus (MHV) and human coronavirus 229E (HCoV229E)
- Inhibits human cardiac ion channels hERG, Nav1.5, and Cav1.2
- Exhibits microsomal and mouse plasma stability
- Displays Caco-2 cell permeability
Product Title
By clicking Submit, you acknowledge that you may be contacted by Fisher Scientific in regards to the feedback you have provided in this form. We will not share your information for any other purposes. All contact information provided shall also be maintained in accordance with our Privacy Policy.
Spot an opportunity for improvement?