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Medchemexpress LLC 5-Pyrimidineacetic acid, 4,6-bis(dimethylamino)-2-[[4-[[4-(trifluoromethyl)benzoyl]amino]phenyl]me | 1093108-50-9 | 99.4% | 501.50 | 100 MG
SDP

Supplier:  Medchemexpress LLC HY114141100MG

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BI-671800 is a highly specific and potent antagonist of chemoattractant receptor-homologous molecule on Th2 cells (DP2/CRTH2), with IC50 values of 4.5 nM and 3.7 nM for PGD2 binding to CRTH2 in hCRTH2 and mCRTH2 transfected cells, respectively. It has potential for the treatment of poorly controlled asthma.

  • Highly specific and potent antagonist of chemoattractant receptor-homologous molecule on Th2 cells (DP2/CRTH2).
  • Exhibits low nM potency as an antagonist of human or mouse CRTH2 in transfected cells.
  • Shows significant inhibition of AHR in mice.
  • Effectively blocks edema formation and greatly reduces inflammatory infiltrate and skin pathology.

Catalog No. 50-004-37288


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