Medchemexpress LLC 5-pyrimidineacetic acid, 4,6-bis(dimethylamino)-2-[[4-[[4-(trifluoromethyl)benzoyl]amino]phenyl]methyl]- | 1093108-50-9 | 99.4% | 501.50 | 50 MG

Supplier:  Medchemexpress LLC HY11414150MG

This product is a highly specific and potent antagonist of chemoattractant receptor-homologous molecule on Th2 cells (DP2/CRTH2), with IC50 values of 4.5 nM and 3.7 nM for PGD2 binding to CRTH2 in hCRTH2 and mCRTH2 transfected cells, respectively. It has potential for the treatment of poorly controlled asthma. It can also significantly inhibit AHR in mice and effectively block edema formation while reducing inflammatory infiltrate and skin pathology in drug vehicle-treated animals.

• Highly specific and potent antagonist of CRTH2.
• Demonstrates low nanomolar potency against human and mouse CRTH2 in transfected cells.
• Shows significant inhibition of airway hyperreactivity (AHR) in mice.
• Effectively blocks edema formation in animal models.
• Reduces inflammatory infiltrate and skin pathology.
• Potential for treating poorly controlled asthma.

Catalog No. 50-004-35968