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ABclonal Technology 594 Rabbit anti-Human CD204
SDP

Supplier:  ABclonal Technology A25615500T

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This gene encodes class A macrophage scavenger receptors which include three isoforms (1 2 and 3) generated by alternative splicing These trimeric membrane glycoproteins are macrophage-specific and involved in various physiological and pathological processes such as atherosclerosis Alzheimer s and host defense Isoforms 1 and 2 are functional receptors that mediate endocytosis of modified low-density lipoproteins (LDLs) while isoform 3 despite containing the LDL-binding domain does not internalize modified LDL due to altered intracellular processing trapping it in the endoplasmic reticulum Isoform 3 can inhibit isoforms 1 and 2 when co-expressed suggesting a regulatory mechanism for scavenger receptor activity in macrophages

Catalog No. 50-000-11017


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