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Cayman Chemical 5a 6-DIhydroxycholestnol 10mg
Supplier: Cayman Chemical 2553810 MG
An oxysterol metabolite of cholesterol; inhibits NMDA-mediated calcium influx in HEK293 cells expressing NR1/NR2B NMDA receptors; binds to Nav channels and decreases action potentials in hippocampal neurons in vitro at 10 µM; increases survival of spinal cord motoneurons, cortical neurons, and cerebellar granule neurons in vitro at 5-15 µM; neuroprotective in a rat model of cerebral ischemia at 12 mg/kg ; increases latency to seizure onset and reduces severity of PTZ-induced seizures in rats; has been used as a replacement for cholesterol in the study of cholesterol binding proteins
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