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Cayman Chemical 5Z 11Z 15R15HydroxyeIcosa

Supplier: Cayman Chemical 19557250 UG

A potent inhibitor of B-RafV600E (Kd 14 nM in an in vitro binding assay) blocks B-RafV600E dependent phosphorylation of MEK in human melanoma A375 and colorectal cancer COLO 205 cells (IC50s 78 and 60 nM respectively) displays good oral bioavailability
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