Cayman Chemical 5Z-7-Oxozeaenol 1mg

Supplier:  Cayman Chemical 174591 MG

A TAK1 inhibitor (IC50 = 8.1 nM in the presence of TAB1); selective for TAK1 over MEK1 and MEKK1 (IC50s = 411 and 268 nM, respectively), as well as ASK1 and IKKβ at 300 nM; inhibits NF-κB activity in a reporter assay using HEK293 cells expressing TAK1 and TAB1 (IC50 = 83 nM); reduces IL-1-induced increases in COX-2 levels in MEFs; sensitizes HeLa cells to TRAIL-induced apoptosis at 300 nM; induces necroptosis when used in combination with TNF and zVAD in primary mouse BMDMs at 100 nM; topical application prevents picryl chloride-induced increases in EAr thickness in mice

Catalog No. 50-298-0181