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Medchemexpress LLC 6-(4-((5-chloro-4-((4-chlorophenyl)amino)pyrimidin-2-yl)amino)-1H-pyrazol-1-yl)-N-hydroxyhexanamide | 2284621-75-4 | 98.5% | 450.32 | C19H21Cl2N7O2 | 50MG
Supplier: Medchemexpress LLC HY12614150MG
JAK/HDAC-IN-1 is a small-molecule dual inhibitor of Janus kinases and histone deacetylases that exhibits low-nanomolar biochemical potency and antiproliferative, proapoptotic activity in hematological cell lines. The compound includes solubility and storage guidance for research applications and is provided as a high-purity research reagent.
- Dual JAK and HDAC inhibitory activity with low-nanomolar IC50s (example: JAK2 4 nM; HDAC 2 nM).
- Demonstrated antiproliferative and proapoptotic effects in hematological cell lines.
- Molecular formula C19H21Cl2N7O2; molecular weight 450.32.
- Soluble in DMSO (~20.83 mg/mL) and formulatable for in vivo dosing at ≥2.08 mg/mL in recommended vehicles.
- Storage: keep at 4°C protected from light; in solution store at -80°C (6 months) or -20°C (1 month) protected from light.
- Reported purity approximately 98.5%.
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