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Medchemexpress LLC 6-(4-methylpiperazin-1-yl)-N-(5-methyl-1H-pyrazol-3-yl)-2-[(E)-2-phenylethenyl]pyrimidin-4-amine | 934353-76-1 | MFCD16619371 | 100.0% | 375.47 | 10 MG
SDP

Supplier:  Medchemexpress LLC HY10987A100MG

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ENMD-2076 is a multi-targeted kinase inhibitor that selectively binds to and inhibits tyrosine and Aurora kinases. This action can lead to the inhibition of cell division and proliferation, and may induce apoptosis in tumor cells. It also exhibits antiangiogenic activity, making it suitable for various research applications.

  • Inhibits multiple kinases including Aurora A, Flt3, KDR/VEGFR2, and FGFR1.
  • Demonstrates antiproliferative activity against human cell lines.
  • Induces G2-M-phase arrest and apoptosis.
  • Inhibits Flt3 ligand (FL)-induced Flt3 autophosphorylation.
  • Inhibits VEGFR2/KDR autophosphorylation.
  • Shows dose-dependent inhibition of tumor growth in vivo.

Catalog No. 50-003-44443


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