6(5H)-Phenanthridinone, 96%

Description

CAS: 1015-89-0 | C13H9NO | 195.221 g/mol

6(5H)-Phenanthridinone is used as a probe into the role of PARP in cellular response to irradiation. Treatment of cells with 6(5H)-Phenanthridinone and various DNA-damaging agents showed a resistance to apoptosis. It acts as a reactant in the synthesis of 5,6-dihydrophenanthridine sulfonamides, oxidative coupling with diphenylacetylene, direct copper acetate-catalyzed N-cyclopropylation of cyclic amides. It is used as HIV-1 integrase inhibitor.

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

Applications
6(5H)-Phenanthridinone is used as a probe into the role of PARP in cellular response to irradiation. Treatment of cells with 6(5H)-Phenanthridinone and various DNA-damaging agents showed a resistance to apoptosis. It acts as a reactant in the synthesis of 5,6-dihydrophenanthridine sulfonamides, oxidative coupling with diphenylacetylene, direct copper acetate-catalyzed N-cyclopropylation of cyclic amides. It is used as HIV-1 integrase inhibitor.

Solubility
Soluble in DMSO (5 mg/ml). Insoluble in water.

Notes
Incompatible materials are oxidizing agents. Store in cool place. Keep container tightly closed in a dry and well-ventilated place.

Specifications

Chemical Identifiers

• CAS: 1015-89-0
• Molecular Formula: C13H9NO
• Molecular Weight (g/mol): 195.221
• MDL Number: MFCD00004988
• InChI Key: RZFVLEJOHSLEFR-UHFFFAOYSA-N
• Synonym: 6 5h-phenanthridinone, phenanthridin-6 5h-one, 6-phenanthridinol, phenanthridone, 6-5h-phenanthridinone, 6-phenanthridone, 6-phenanthridinone, 6 5h-phenanthridone, phenanthridin-6-ol, phenantridone
• PubChem CID: 1853
• ChEBI: CHEBI:75292
• IUPAC Name: 5H-phenanthridin-6-one
• SMILES: C1=CC=C2C(=C1)C3=CC=CC=C3NC2=O

• Melting Point: 288°C to 294°C
• Quantity: 5 g
• Beilstein: 140641
• Solubility Information: Soluble in DMSO (5mg/ml). Insoluble in water.
• Formula Weight: 195.22
• Percent Purity: 96%
• Chemical Name or Material: 6(5H)-Phenanthridinone

Safety and Handling

EINECSNumber	213-804-3
RTECSNumber	SG0370000
TSCA	No
Recommended Storage	Ambient temperatures

SDS

RUO – Research Use Only