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Cayman Chemical 6(5H)-Phenanthridinone, Purity: ≥98%, CAS: 1015-89-0, 10 mg
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Catalog No. 502939277
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An inhibitor of PARP1 and 2 (EC50s = 10.2 and 36.3 μM, respectively, in yeast cells expressing the human enzymes); decreases radiation-induced PARP activity and proliferation of RDM4 murine lymphoma cells at 50 μM; reduces NF-κB-induced transcription of the genes encoding TNF-α, IL-2, and IFN-γ in rat lymphocytes; reduces spinal cord expression of iNOS, IL-1β, TNF-α, IL-2, and IFN-γ and reduces disease score in a rat model of EAE at 60 mg/kg; decreases serum levels of lactate dehydrogenase as well as hepatic lipid peroxidation, oxidative DNA damage, and PARP levels in a mouse model of carbon tetrachloride-induced hepatotoxicity at 10 mg/kg

Catalog No. 50-293-9277 Supplier Cayman Chemical Supplier No. 2873010 MG
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An inhibitor of PARP1 and 2 (EC50s = 10.2 and 36.3 μM, respectively, in yeast cells expressing the human enzymes); decreases radiation-induced PARP activity and proliferation of RDM4 murine lymphoma cells at 50 μM; reduces NF-κB-induced transcription of the genes encoding TNF-α, IL-2, and IFN-γ in rat lymphocytes; reduces spinal cord expression of iNOS, IL-1β, TNF-α, IL-2, and IFN-γ and reduces disease score in a rat model of EAE at 60 mg/kg; decreases serum levels of lactate dehydrogenase as well as hepatic lipid peroxidation, oxidative DNA damage, and PARP levels in a mouse model of carbon tetrachloride-induced hepatotoxicity at 10 mg/kg

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