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Medchemexpress LLC 6-[(aminocarbonyl)(2,6-difluorophenyl)amino]-2-(2,4-difluorophenyl)-3-pyridinecarboxamide | 745833-23-2 | MFCD11616590 | >98.0% | 404.32 | C19H12F4N4O2 | 200 MG
SDP

Supplier:  Medchemexpress LLC HY10401200MG

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VX-702 is a research-grade small-molecule inhibitor selective for p38α mitogen-activated protein kinase (MAPK). It exhibits approximately 14-fold higher potency for p38α versus p38β and has demonstrated both in vitro and in vivo activity in preclinical inflammatory models. The compound is supplied as a high-purity material suitable for biochemical, cellular, and pharmacology studies.

  • Selective p38α MAPK inhibition with approximately 14-fold selectivity versus p38β.
  • Potent in vitro activity with reported IC50 values in the ~4-20 nM range.
  • Reduces proinflammatory cytokine production (IL-6, IL-1β, TNFα) in dose-dependent studies.
  • Documented in vivo pharmacokinetics, including a reported half-life of 16-20 hours.
  • Supplied at high purity (>98%).
  • Soluble in DMSO at ≥42 mg/mL for assay preparation.
  • Intended for research use only.

Catalog No. 50-002-42623


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