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AdipoGen 6-Carboxy-DCF DA
Supplier: AdipoGen CDXC0334M100
Chemical. CAS 144489-10-1. Formula C25H14Cl2O9. MW 529.29. Fluorescent indicator. The non-fluorescent 6-CDCF DA passively diffuses across the cell membrane and is hydrolyzed to fluorescent CDCF by intracellular esterases. It has been shown to be highly sensitive, long-lasting, cell-permeant and fluorescein-based tracer for quantifying ROS generation. Substrate for MRP2 and MRP3 and therefore the function of the efflux transporters hepatic exrection and multi-drug resistance associated proteins MRP2 and MRP3 can be measured using 6-CDCF DA. The CDCFDA/CDCF technoique provides a fast screening tool for MRP2 substrates and/or inhibitors. Spectral data lambdaEx=502nm lambdaEm=530nm.
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