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Cayman Chemical 6-O-SulfocyclodextrInsod 100mg
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Supplier:  Cayman Chemical 30168100 MG

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A SMN2 splicing modifier enhances SMN2 splicing (EC1 5x 40 nM) and increases SMN protein levels (EC1 5x 163 nM) in cellular assays increases brain and quadricep muscle SMN protein levels in the adult C/C-allele mouse model of SMA and the SMND7 neonate mouse model of severe SMA at 3 mg/kg increases vGLUT1 proprioceptive inputs on motor neurons the number of L3-L5 motor neurons the percentage of fully innervated NMJs and the size of the extensor digitorum longus muscles in adult SMND7 mice

Catalog No. 50-298-9141


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