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Cayman Chemical 6-OHDAhydrobromIde 50mg
Supplier: Cayman Chemical 2533050 MG
A catecholaminergic neurotoxin; has been used to induce dopaminergic lesions and parkinsonian symptoms as a model of Parkinson's disease in rodents; induces locomotor impairment in mice and loss of tyrosine hydroxylase-reactive neurons in mouse brain when administered into the substantia nigra, MFB, or striatum at doses of 9, 6, and 18 μg, respectively; decreases dopamine and norepinephrine levels in rat brain at 200 μg; induces apoptosis in primary rat cortical cells and PC12 rat adrenal cells at 50 μM; activates caspase-3, -8, and -9 in a time-dependent manner and increases the level of intracellular ROS in PC12 cells at 75 μM; induces apoptosis in rat substantia nigra when stereotaxically injected into the right MFB
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