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Medchemexpress LLC 6-Thio-2'-Deoxyguanosine | 789-61-7 | 99.7% | 283.31 | 50 MG
Supplier: Medchemexpress LLC HY1876250MG
6-Thio-2'-Deoxyguanosine is a nucleoside analogue that can be incorporated into de novo-synthesized telomeres by telomerase. It causes rapid cell death for the majority of cancer cell lines tested with IC50s between 0.7-2.9 μM. In A549 lung cancer cell-based mouse xenograft studies, it decreases tumor growth rate and increases telomere dysfunction in tumor cells in vivo.
- Nucleoside analogue
- Incorporated into de novo-synthesized telomeres by telomerase
- Results in rapid cell death for the vast majority of cancer cell lines tested with IC50s of between 0.7-2.9 μM
- Causes a decrease of the tumor growth rate in A549 lung cancer cell-based mouse xenograft studies
- Increases telomere dysfunction in tumor cells in vivo
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