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Apexbio Technology LLC 6-Thio-dG 789-61-7 50mg
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Supplier:  Apexbio Technology LLC B600950

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6-Thio-2 -deoxyguanosine (6-Thio-dG CAS 789-61-7) is a nucleoside analogue that functions as a telomerase-mediated telomere targeting agent In telomerase-positive cancer cells 6-Thio-dG is incorporated into telomeric DNA inducing rapid telomere dysfunction independent of direct telomerase inhibition which leads to growth arrest and cell death In vitro cancer cell lines exhibit IC50 values ranging from 0 7 to 2 9 M indicating high sensitivity to the compound Normal cells with telomerase-silent status show minimal morphological effects upon 6-Thio-dG exposure In vivo 6-Thio-dG administration inhibits tumor growth and reduces proliferation markers in xenograft models The compound is valuable for investigating telomere biology and as a tool to evaluate telomerase-dependent therapeutic strategies in cancer research

Catalog No. 50-000-87794


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